A mutualistic symbiosis between a parasitic mite and a pathogenic virus undermines honey bee immunity and health

Please place treatment free research here. There's a lot of research spread around the Internet that is related to treatment free beekeeping. This forum is an effort to try and consolidate some of this, especially new research as it becomes available.
User avatar
ExpatBeekeeper
Backyard Beekeeper
Posts: 121
Joined: Wed May 20, 2015 3:27 am
Location: Richmond, VA

A mutualistic symbiosis between a parasitic mite and a pathogenic virus undermines honey bee immunity and health

Postby ExpatBeekeeper » Wed Mar 16, 2016 5:08 pm

Abstract
Honey bee colony losses are triggered by interacting stress factors consistently associated with high loads of parasites and/or pathogens. A wealth of biotic and abiotic stressors are involved in the induction of this complex multifactorial syndrome, with the parasitic mite Varroa destructor and the associated deformed wing virus (DWV) apparently playing key roles. The mechanistic basis underpinning this association and the evolutionary implications remain largely obscure. Here we narrow this research gap by demonstrating that DWV, vectored by the Varroa mite, adversely affects humoral and cellular immune responses by interfering with NF-κB signaling. This immunosuppressive effect of the viral pathogen enhances reproduction of the parasitic mite. Our experimental data uncover an unrecognized mutualistic symbiosis between Varroa and DWV, which perpetuates a loop of reciprocal stimulation with escalating negative effects on honey bee immunity and health. These results largely account for the remarkable importance of this mite–virus interaction in the induction of honey bee colony losses. The discovery of this mutualistic association and the elucidation of the underlying regulatory mechanisms sets the stage for a more insightful analysis of how synergistic stress factors contribute to colony collapse, and for the development of new strategies to alleviate this problem.

PNAS-2016-Di Prisco-1523515113.pdf
(1007.5 KiB) Downloaded 36 times
Beekeeper, Meadmaker, Teaboy, and Gopher. Richmond, VA

Return to “Scientific Research”

Who is online

Users browsing this forum: No registered users and 1 guest